Osteopoikilosis (Spotted Bone Disease)

A 23-year-old male had swelling of both knees. He had a history of a similar problem 18 months ago, treated with joint aspiration and non-steroidal anti-inflammatory drugs. There was no other significant history. However, the clinical examination revealed another swelling of enthesitis near the left ankle. His X-ray revealed osteopoikilosis. Arthritis was treated with non-steroidal anti-inflammatory drugs and settled over 6-8 weeks.

Osteopoikilosis is an inherited condition of small, rounded, or oval, multiple, symmetric areas of bone sclerosis (increased density) occurring near growing ends and the adjacent regions of bones. These densities appear in childhood and persist throughout life. They do not cause any symptoms nor require any treatment.

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